Abstract Search

ea0029p80 | Adrenal cortex | ICEECE2012

RRM1 Gene expression affects metabolization and activity of mitotane in adrenocortical cancer cell lines.

Germano A. , Rapa I. , De Francia S. , Volante M. , Laino F. , Duregon E. , Berruti A. , Papotti M. , Terzolo M.

Background: Mitotane (o,pDDD) is the reference therapy for adrenocortical carcinoma (ACC) and should undergo metabolization in o,pDDE and o,pDDA to exert its anti-proliferative activity. We have previously shown that there is a link between RRM1 gene expression and o,pDDD activity in an adjuvant setting. Aim of this study was to assess whether RRM1 gene expression is correlated to the bioavailability and cytotoxic activity of o,pDDD and its metabo...

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ea0029p31 | Adrenal cortex | ICEECE2012

Analysis of the glucocorticoid receptors polymorphism in patients with adrenal incidentaloma and patients with Cushing’s syndrome.

Reimondo G. , Giachino D. , Micossi I. , Berchialla P. , Varacalli S. , Allasino B. , Pia A. , Laino F. , Peraga G. , Cosio P. , Sciolla C. , De Marchi M. , Terzolo M.

The effects of glucocorticoids are mediated by the glucocorticoid receptors (GR) and some single nucleotide polymorphisms (SNPs) have been associated to enhanced sensitivity (N363S, BclI) or reduced sensitivity (ER22/23EK) to glucocorticoids.Aim of the present study was: 1) to assess the frequency of N363S, BclI and ER22/23EK in 46 patients with Cushings syndrome (CS) and 73 patients with adrenal incidentaloma (AI) compared to 186 healthy subjects;...

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Endocrine Abstracts

RRM1 Gene expression affects metabolization and activity of mitotane in adrenocortical cancer cell lines.

Analysis of the glucocorticoid receptors polymorphism in patients with adrenal incidentaloma and patients with Cushing’s syndrome.

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